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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Neuroscience. 2021 Sep 28;478:49–64. doi: 10.1016/j.neuroscience.2021.09.016

Figure 3.

Figure 3.

PACAP shows no effect in OVX wildtype female mice. A & B, Pronounced increases in energy expenditure triggered by the binge episode; with heat production being potentiated by EB (A). C & D, EB (20 μg/kg; s.c.; n = 6) but not PACAP (30 pmol; VTA; n = 6) decreases binge intake as well as the percent of the daily intake consumed during the binge hour as compared to their sesame oil (n = 6) and saline controls (n = 6). E, Chow consumption over the remaining 23 hours is significantly reduced in EB- and PACAP-treated animals. Bars represent means and lines 1 SEM. Box-and-whisker plots illustrate the median, 25th and 75th quartiles, as well as the 5th and 95th percentiles. #, p < 0.05 with respect to time (A & B); *, p < 0.05; with respect to saline; ^, p < 0.05 with respect to sesame oil; repeated measures, multi-factorial ANOVA/LSD (A – C, E), rank-transformed, repeated measures, multi-factorial ANOVA/LSD (D).