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The outward current obtained in A10 dopamine neurons from TH-cre mice is also associated with a hyperpolarization and decrease in firing. A, Current clamp trace illustrating that bath application of PACAP1–38 produces reversible hyperpolarization that significantly lowers the membrane potential (Vm; B) and suppresses firing (C). B & C, Bars represent means and lines 1 SEM (n = 6). *, p < 0.05 relative to PACAP alone, Student’s t-test (B), signed rank test (C).
