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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Kidney Int. 2021 Jul 1;100(6):1179–1184. doi: 10.1016/j.kint.2021.05.040

Table 1 |.

Genetic and genomic lineage tracing tools

Class Method Model Labelling Analysis Reference
Genetic Single-color One cell-specific recombinase line and one reporter line (mouse) Constitutive or tamoxifen induction Microscope 1,2
Intersectional Two cell-specific recombinase lines and one reporter line (mouse) Constitutive or tamoxifen induction Microscope 9,13,14,17
3D lineage tracing Single-color or intersectional lineage tracing mouse model Constitutive or tamoxifen induction Optic clearing and Microscope 19,20,21
Genomic CellTagging Culture cells Lentiviral tag transduction scRNA-seq 23
Polylox Cell-specific, inducible Cre line and Rosa26-Polylox knock-in mouse line Tamoxifen induction DNA-seq 24
PolyloxExpress Cell-specific, inducible Cre line and Rosa26-PolyloxExpress knock-in mouse line Tamoxifen induction scRNA-seq 25
GESTALT GESTALT barcode transgenic zebrafish Cas9 protein and sgRNAs injection DNA-seq 26
scGESTALT scGESTALT barcode transgenic zebrafish line and inducible Cas9 zebrafish line Cas9 protein and sgRNAs injection /Heat shock scRNA-seq 27
CARLIN CARLIN mouse line and rtTA transgenic mouse line (Tet-ON) Doxycycline scRNA-seq 28