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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Am J Ophthalmol. 2021 Jun 6;231:179–193. doi: 10.1016/j.ajo.2021.06.004

TABLE 2.

Quantification of Lesion Area and Intergrader Agreement in Lesion Localization

Lesion Area (mm2)
 Pairwise Intergrader Agreement (DSC)
 Lesion Features
Eye Diagnosis HG1 HG2 AG HG1 vs HG2 HG1 vs AG HG2 vs AG CNVM Poor-Contrast Boundaries Disease Status
1 SC 15.97 15.82 16.14 0.96 0.95 0.97 N N Inactive
2 SC 3.19 3.49 3.20 0.96 0.95 0.95 N N Inactive
3 SC 4.61 4.86 4.93 0.94 0.88 0.88 N N Active
4 BSCR 0.63 0.90 0.79 0.82 0.87 0.87 Ya N Inactive
5 POHS 5.24 4.64 3.66 0.90 0.81 0.86 Ya N Inactive
6 MFC 2.94 3.44 2.44 0.88 0.80 0.86 N N Active
7 RPC 8.37 9.00 6.94 0.87 0.85 0.86 N Y Inactive
8 RPC 14.75 13.35 10.34 0.90 0.80 0.85 N N Inactive
9 SC 22.02 22.56 16.11 0.99 0.84 0.83 N N Inactive
10 SC 29.77 31.48 21.90 0.96 0.84 0.82 N N Inactive
11 MFC 1.22 2.00 1.74 0.69 0.71 0.82 N N Inactive
12 SC 18.79 16.39 12.48 0.87 0.77 0.80 N Y Active
13 BSCR 9.23 9.00 6.00 0.83 0.72 0.77 N N Inactive
14 BSCR 13.54 18.61 11.66 0.83 0.81 0.76 N Y Inactive
15 BSCR 5.60 5.22 5.50 0.75 0.67 0.71 N Y Inactive
16 POHS 7.24 5.40 4.62 0.81 0.70 0.66 N Y Inactive
17 MFC 11.44 11.31 5.33 0.93 0.61 0.64 Y N Inactive
18 MFC 2.14 3.62 2.82 0.83 0.59 0.62 N Y Inactive
19 BSCR 19.68 20.63 709 0.94 0.53 0.51 Y Y Inactive
20 AMPPE 12.20 9.60 2.33 0.79 0.31 0.37 N Y Inactive
Mean (SD): 10.72 (8.02) 10.6 (8.15) 7.3 (5.70) 0.87 (0.08) 0.75 (0.15) 0.77 (0.15)

AG = algorithm; AMPPE = acute multifocal pigment placoid epitheliopathy; BSCR = birdshot chorioretinopathy; CNVM = choroidal neovascular membrane; HG1 = human grader 1; HG2 = human grader 2; MFC = multifocal choroiditis; POHS = presumed ocular histoplasmosis syndrome; RPC = relentless placoid chorioretinopathy; SC = serpiginous choroiditis.

a

Eyes with CNVM reported in the clinical chart, but without neovascularization visible on the choriocapillaris en face image. Twenty eyes were analyzed. The total lesion area (mm2) per image is listed by grader: HG1, HG2, and AG. Agreement in lesion localization between graders was measured by pairwise Sørensen-Dice coefficient (DSC). Eyes are listed in order of highest to lowest DSC between the AG and HG2. Shaded in gray are 4 eyes that demonstrated poor agreement (DSC <0.70) between the AG and both human graders.