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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Kidney Int. 2021 Oct 9;100(6):1250–1267. doi: 10.1016/j.kint.2021.08.031

Figure 1. AAI toxicity results in PT injury, fibrosis, and reduced KLF15 expression.

Figure 1.

Wildtype mice were administered DMSO or AAI for 2 weeks, and examined 3 days later (active phase) or 2 weeks later (remodeling phase). (a) Histological analysis using Hematoxylin and Eosin (H&E), and periodic acid-Schiff (PAS) stains. (b-e) Immunofluorescent staining for: aristolactam (AL)-DNA adducts, with counterstaining for Lotus lectin (LL) and DAPI (b), COL1α1 (c), α-SMA (d), and KLF15 with counterstaining for LL and DAPI (e). Representative images provided from each group (n=6 per group). Scale bars = 100μm, insets are 150μm × 150μm.