Table 2.
Biomarkers levels at sepsis diagnosis.
| Biomarker | Total sepsis (N = 232) |
Sepsis without IMV (N = 81) |
Sepsis with IMV (N = 151) |
Extrapulmonary sepsis (N = 141) |
Pulmonary sepsis (N = 86) |
|---|---|---|---|---|---|
| RAGE (pg/mL) | 1019.66 (563.37–2066.59) | 750.19 (440.10–1181.38) | 1371.12*** (645.05–2581.35) | 828 (455.34–1408.46) | 1825..38### (848.91–3089.29) |
| PAI-1 (pg/mL) | 73.12 (43.08–140.18) | 58.80 (36.00–108.94) | 82.93* (46.50–202.72) | 84.87 (47.47–165.21) | 55.35# (38.06–112.48) |
| SP-D (ng/mL) | 5.80 (2.54–11.39) | 4.17 (1.79–8.81) | 6.73** (2.89–13.47) | 4.46 (1.81–8.85) | 8.03### (4.39–16.87) |
| IL-18 (pg/mL) | 543.17 (300.71–1056.15) | 521.28 (297.19–920.67) | 559.11 (303.20–1153.49) | 505.52 (297.19–985.91) | 567.51 (302.01–1000.91) |
| Ang-2 (pg/mL) | 4467.88 (2169.10–8352.27) | 5302.58 (3070.03–10,110.21) | 3851.28* (1906.46–8105.40) | 5524.24 (2885.51–10,360.47) | 2914.04### (1325.90–5616.83) |
| ICAM-1 (ng/mL) | 356.71 (261.70–518.09) | 324.27 (255.99–516.93) | 383.21 (261.18–525.07) | 372.55 (271.29–573.70) | 325.62# (233.10–489.05) |
| CXCL16 (pg/mL) | 4255.27 (2771.32–6361.93) | 2985.59 (2269.12–4241.76) | 5020.01*** (3400.91–7133.91) | 4229.28 (2,857,035–6040.27) | 4286.74 (2620.53–6474.89) |
| AREG (pg/mL) | 38.05 (20.20–82.94) | 29.87 (7.80–64.97) | 45.81** (26.55–101.06) | 38.98 (23.02–79.81) | 37.21 (16.11–98.12) |
| IL-1RA (pg/mL) | 603.74 (19.55–3248.49) | 232.32 (19.55–232.32) | 820.32 (19.55–10,325.96) | 816.98 (19.55–4950.81) | 239.92 (19.55–1932.36) |
Concentrations are given as median (Q1–Q3).
N is the number of samples in each group.
IMV invasive mechanical ventilation.
*P < 0.05, **P < 0.01 and ***P < 0.001 for the comparison of sepsis with and without IMV.
#P < 0.05 and ###P < 0.001 for the comparison of extrapulmonary and pulmonary sepsis.