Table 3.

Comparison of patient-level accuracy between classification tasks. The performance in detecting EBV + MSI/dMMR subgroup is shown for “EBV + MSI vs. others” and “EBV vs. MSI vs. others” tasks, whereas the values of “EBV vs. MSI + others” and “MSI vs. EBV + others” tasks are performances for detecting EBV and MSI/dMMR, respectively. “Combination of 3) and 4)” shows the performance for detecting EBV + MSI/dMMR based on the results of 3) and 4) tasks. EBV, Epstein-Barr virus; MSI, Microsatellite instability; dMMR, Mismatch repair deficiency; AUC, Area under the curve; CI, Confidence interval.

Classification task	Sensitivity	Specificity	AUC (95%CI)
(1) EBV + MSI vs. others	0.879 (29/33)	0.878 (43/49)	0.947 (0.901–0.992)
(2) EBV vs. MSI vs. others	0.909 (30/33)	0.837 (41/49)	0.931 (0.876–0.986)
(3) EBV vs. MSI + others	0.857 (18/21)	0.951 (58/61)	0.980 (0.956–1.000)
(4) MSI vs. EBV + others	0.833 (10/12)	0.814 (57/70)	0.880 (0.759–1.000)
Combination of (3) and (4)	0.879 (29/33)	0.735 (36/49)	−