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. 2021 Nov 22;12(12):1097. doi: 10.1038/s41419-021-04386-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A, B MIAT expression was reduced in TPC-1 and BCPAP cells transfected with sh-MIAT, but increased in cells transfected with pcDNA3.1- MIAT. C The western blot of p27, p16, and p15. D, E The migratory abilities of TPC-1 and BCPAP cells were determined using transwell assay. F, G The apoptosis rate stained and analyzed by flow cytometry of TPC-1 and BCPAP cells were increased when MIAT were inhibited. E2, early apoptotic cells; E4, terminal apoptotic cells. The Y axis represents the apoptosis rate (E2 + E4). H The western blot of apoptosis-related protein including cleaved PARP and cleaved casp3 in TPC-1 and BCPAP cells. I TPC-1 and BCPAP cells were transfected with sh-NC/sh-MIAT or pcDNA3.1/pcDNA3.1- MIAT, cell viability was analyzed by CCK-8 assay. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control cells, n.s. non-significant, using two-tailed t-test analysis.