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. 2021 Nov 22;12(12):1097. doi: 10.1038/s41419-021-04386-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A An ceRNA network including 15 lncRNAs, 28 miRNAs, and hundreds of mRNAs were involved. The red dot represented the lncRNA, the blue dot represented the miRNA and the green ones represented the mRNA. B Construction of the ceRNA network demonstrated a relationship among lncRNA-MIAT, miR-150-5p, and EZH2. C MIAT, miR-150-5p and EZH2, LDLR, SMC3, SAR1A, PERP, MTCH2 expression in cancer tissue and para-cancer tissues. D The western blot of EZH2, LDLR, SMC3, SAR1A, PERP, MTCH2 in cancer and para-cancer tissues. E MIAT, miR-150-5p, and EZH2 expression in NTHY, TPC-1, K1, and BCPAP cells. F miR-150-5p and EZH2 expression in TPC-1 and BCPAP cells when sh-MIAT and pc-MIAT were used. G The Pearson’s correlation between lncRNA-MIAT, miR-150-5p, and EZH2 in PTC tissues. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control cells, n.s. non-significant, using two-tailed t-test analysis.