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. 2021 Nov 22;12:6777. doi: 10.1038/s41467-021-26926-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The reversed phase-ion pair high performance liquid chromatography (RP-IP HPLC) chromatogram of mRNA extracted from the mRNA-lipid nanoparticle (mRNA-LNP, black) is overlaid with RP-IP HPLC re-analysis of isolated mRNA main peak (MP, blue) and late eluting-peak (LP, red), showing preserved retention time of each isolated region. b The capillary electrophoresis (CE) electropherogram of mRNA extracted from the mRNA-LNP (black) is overlaid with electropherograms of the isolated MP (blue) and LP (red), showing no difference in migration time. c The size-exclusion chromatography (SEC) chromatograms of mRNA extracted from the mRNA-LNP (black) is overlaid with SEC chromatograms of isolated MP (blue) and LP (red), showing no presence of aggregation in either fraction. Representative data from 4 repeat experiments are shown. AU, absorption units.