Fig. 7.

Analysis of the effect of OEA on social behavior along cerebellar degeneration. (a) Schematic representation of the three-chambered social preference test. (b–f) Quantification of the percentage of time spent exploring the chamber, containing either an intruder or an object, by WT, PCD, and treated PCD at different ages; note that the normal social behavior was impaired in nontreated PCD mice from P17 onward, whereas treated PCD animals maintained a normal social pattern until P30. (g) Chart showing the sociability index at different ages for WT, PCD, and treated PCD animals; similar values were observed in WT and treated PCD mice until P30, at which time the treated PCD subjects showed an intermediate score between WT and nontreated PCD mice. (h) Quantification of the number of visits to both objects at P30 and P40; a decrease in the number of visits was detected in nontreated PCD mice at P40. Data are represented as mean ± SEM; n = 8–9 each experimental group; Student’s t test for (b–f); one-way ANOVA followed by Bonferroni’s post hoc test for (g, h); *p < 0.05; **p < 0.01