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. 2021 Nov 22;4:1318. doi: 10.1038/s42003-021-02856-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Representative SP-NIRF intensity-time profile at the ROIs for T1 (anti-ACE2 antibody) and T2 (anti-SP antibody) in 2- to 3-month-old mice after its intravenous injection. c Peak intensity for the ROIs. d Area under the curve (AUC) for the ROIs. e Semi-Ln plots for the intensity-time profile of the neck, thorax, and lower abdomen ROIs (continuous line (control); dashed line (anti-ACE2 antibody) and dotted line (anti-SP antibody). f Elimination rate constants for the neck, thorax, and lower abdomen. g Slopes for the accumulation phase for the upper abdomen. h Intensity-time profile of the paw. i Organ SP-NIRF intensities/mg wet weight at 60 min. Values are mean ± SEM, N = 4 young male mice. AU (arbitrary units).