Table 1.
Characteristics of study population from ESTHER study
| Characteristics | Subset I (n=741) | Subset II (n=1030) | P-valuea |
|---|---|---|---|
| Age (years; mean ± SD) | 61·7±6·6 | 62·0±6·7 | 0·24 |
| Sex (N/%) | |||
| Men | 326 (44·0) | 452 (43·9) | 0·96 |
| Women | 415 (56·0) | 578 (56·1) | |
| Educational levels (N/%)b | |||
| Low (≤9 years) | 532 (74·0) | 770 (76·5) | 0·36 |
| Intermediate (10-11 years) | 112 (15·6) | 133 (13·2) | |
| High (≥12 years) | 75 (10·4) | 103 (10·2) | |
| Body mass index (N/%)c | |||
| Underweight (<18·5 kg/m2) | 4 (0·5) | 5 (0·5) | 0·98 |
| Normal weight (18·5-<25·0 kg/m2) | 191 (25·8) | 269 (26·2) | |
| Overweight (25·0-<30·0 kg/m2) | 350 (47·3) | 489 (47·7) | |
| Obesity (≥30·0 kg/m2) | 195 (26·4) | 263 (25·6) | |
| Smoking status (N/%)d | |||
| Never smoker | 353 (49·2) | 526 (52·2) | 0·38 |
| Former smoker | 235 (32·7) | 320 (31·8) | |
| Current smoker | 130 (18·1) | 162 (16·1) | |
| Alcohol consumption (grams per day) | 9·3±12·7 | 9·8±12·9 | 0·41 |
| AgeAccelPheno (mean ± SD) | -0·41±5·70 | -0·02±5·78 | 0·17 |
| AgeAccelGrim (mean ± SD) | -0·55±4·55 | 0·01±4·75 | 0·01 |
| MRscore-8CpGs (mean ± SD) | -2·44±0·45 | -2·47±0·46 | 0·18 |
| Frailty index (%; mean ± SD) | 24±14 | 23±14 | 0·19 |
Abbreviations: SD, standard deviation; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs.
a
Chi-square test for categorical variables and analysis of variance for continuous variables.
b
Data missing for 46 participants.
c
Data missing for 5 participants.
d
Data missing for 45 participants.