Table 3.
Associations of DNAm algorithms and frailty index with all-cause mortality after mutual control for each other
| Predictor |
Subset I (n=741) |
Subset II (n=1030) |
Overall (n=1771, meta-analysis) |
|||
|---|---|---|---|---|---|---|
| Cases | HR (95% CI)a | Cases | HR (95% CI)a | Cases | HR (95% CI)a | |
| AgeAccelPheno (per SD) | 194 | 1·18 (1·01-1·39) | 264 | 1·10 (0·95-1·27) | 458 | 1·14 (1·02-1·26) |
| AgeAccelGrim (per SD) | 194 | 1·18 (0·97-1·42) | 264 | 1·34 (1·12-1·59) | 458 | 1·26 (1·11-1·43) |
| MRscore-8CpGs (per SD) | 194 | 1·38 (1·08-1·78) | 264 | 1·43 (1·12-1·82) | 458 | 1·41 (1·18-1·67) |
| FI (%; per SD) | 194 | 1·32 (1·15-1·51) | 264 | 1·22 (1·09-1·38) | 458 | 1·26 (1·16-1·38) |
Abbreviations: FI, frailty index; HR, hazard ratio; CI, confidence interval; SD, standard deviation; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs.
adjusted for age, sex, leukocyte composition (not for FI), batch (not for FI), smoking status (never smoker, former smoker, current smoker), and alcohol consumption (grams per day); results for AgeAccelPheno additionally adjusted for MRscore-8CpGs, AgeAccelGrim and frailty index; results for AgeAccelGrim additionally adjusted for MRscore-8CpGs, AgeAccelPheno and frailty index; results for MRscore-8CpGs additionally adjusted for AgeAccelPheno, AgeAccelGrim and frailty index; results for frailty index additionally adjusted for MRscore-8CpGs, AgeAccelPheno and AgeAccelGrim.