Table 4.
Harrell's C-statistics of chronological age, DNAm algorithms, and frailty index in prediction of all-cause mortality
|
Predictors |
Overall (meta-analysis) Harrell's C statistics (95% CI) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Age+sex+LC | Smoking | AgeAccelPheno | AgeAccelGrim | MRscore-8CpGs | FI (%) | Subset I | Subset II | Overall (meta-analysis) |
| √ | 0·721 (0·661-0·780) | 0·706 (0·674-0·739) | 0·710 (0·681-0·738) | |||||
| √ | √ | 0·752 (0·698-0·806) | 0·731 (0·701-0·760) | 0·736 (0·709-0·762) | ||||
| √ | √ | 0·727 (0·668-0·786) | 0·721 (0·690-0·753) | 0·723 (0·695-0·750) | ||||
| √ | √ | 0·756 (0·700-0·812) | 0·749 (0·720-0·778) | 0·751 (0·725-0·777) | ||||
| √ | √ | 0·760 (0·707-0·812) | 0·746 (0·717-0·776) | 0·750 (0·724-0·776) | ||||
| √ a | √ | 0·741 (0·683-0·799) | 0·719 (0·687-0·751) | 0·724 (0·696-0·752) | ||||
| √ | √ | √ | 0·749 (0·692-0·806) | 0·732 (0·701-0·762) | 0·735 (0·708-0·762) | |||
| √ | √ | √ | 0·769 (0·717-0·821) | 0·756 (0·727-0·785) | 0·758 (0·734-0·784) | |||
| √ | √ | √ | 0·772 (0·722-0·822) | 0·753 (0·723-0·782) | 0·759 (0·732-0·783) | |||
| √ | √ | √ | 0·760 (0·708-0·813) | 0·749 (0·719-0·779) | 0·752 (0·726-0·778) | |||
| √ | √ | √ | 0·768 (0·715-0·822) | 0·757 (0·728-0·786) | 0·759 (0·734-0·785) | |||
| √ | √ | √ | √ | √ | 0·776 (0·724-0·828) | 0·763 (0·734-0·792) | 0·766 (0·741-0·791) | |
Abbreviations: CI, confidence interval; LC, leukocyte composition; AgeAccelPheno, DNA methylation phenotypic age acceleration; AgeAccelGrim, DNA methylation GrimAge acceleration; MRscore-8CpGs, revised version of continuous mortality risk score with 8 CpGs; FI, frailty index.
a
Models did not include leukocyte composition.