Table 2.

Distribution (H-score) of repressive histone marks H3K9me3, H3K27me3, and H4K20me3, and active marks H3K4me3 and H3K36me3 in normal brain (NB) tissues and astrocytomas (grades I–IV)

	H3K9me3	H3K27me3	H4K20me3	H3K4me3	H3K36me3
	Mean (range)/no. of positive cases/total
NB	126 (50–300)/ 5/5	150 (100–200)/ 5/5	50 (50–100)/ 4/5	56 (80–200)/ 2/5	210 (150–300)/ 5/5
Total	216 (45–300)/ 45/46	129 (2–300)/ 46/46	222 (10–300)/ 46/46	193 (30–300)/ 44/46	258 (45–300)/ 46/46
Grade I	199 (50–300)/ 22/22	142 (10–300)/ 22/22	212 (35–300)/ 22/22	190 (75–300)/ 22/22	272 (180–300)/ 22/22
Grade II	191 (45–285)/ 7/7	115 (2–200)/ 7/7	264 (180–300)/ 7/7	170 (50–300)/ 6/7	193 (45–300)/ 7/7
Grade III	300 (300)/ 2/2	120 (90–150)/ 2/2	300 (300)/ 2/2	245 (190–300)/ 2/2	300 (300)/ 2/2
Grade IV	241 (70–300)/ 14/15	119 (5–297)/ 15/15	207 (10–300)/ 15/15	200 (30–300)/ 14/15	261 (120–300)/ 15/15