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. 2021 Nov 22;11:22651. doi: 10.1038/s41598-021-01840-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamic changes in connectivity in the blue and purple modules. (A) and (B) module differential connectivity (MDC) over time in intervals of 10 days for the purple and blue modules, respectively. Solid points indicate a significant difference between cases and controls (FDR < 0.05). (C–F) Direct comparison of topological overlap matrix for cases (upper left triangle) and controls (lower right triangle) at the MDC peak time point. (G) MDC metrics. (H, I) Change in MDC in the purple module correlates with change in the module eigengene (ME). MDC and ME patterns were strikingly similar, except for the last time point before diagnosis in the purple module. The correlated patterns suggest that gene expression influences, MDC but is not the only factor. Solid points indicate a significant difference between cases and controls (P < 0.05). (J, K) Change in MDC in the blue module also correlates with change in ME.