Table 1.

Top 10 differentially connected genes for blue and purple modules.

Module	DCG (ordered by rank)	Infection/cell type signature gene*	Differential connectivity (peak) females	Differential connectivity (peak) males	Differential connectivity p value (MDC peak) females	Differential connectivity p value (MDC peak) males
Blue	TLR8		3.65	5.18	0.02	0.01
	KCNJ15	Neutrophils	3.89	6.76	0.02	0.02
	FCGR2A		3.09	4.97	0.04	0.05
	BEST1	Neutrophils	3.99	3.34	0.04	0.07
	UBR2		5.29	5.67	0.03	0.03
	ALPK1		3.14	4.54	0.05	0.03
	PGCP		6.62	4.27	0.01	0.05
	FPR2		4.92	3.75	0.02	0.03
	PLBD1		7.76	6.34	3 × 10–3	0.02
	MXD1	Neutrophils	2.81	3.25	0.05	0.03
Purple	SAMD9		16.52	3.76	6 × 10–3	0.06
	MX2		9.90	6.52	0.03	0.04
	CMPK2	Monocytes	14.12	7.56	0.04	0.03
	SIGLEC1	Infection	1726.99	12.76	2 × 10–3	0.03
	USP18		30.03	8.99	2 × 10–3	0.04
	IFIH1		15.25	3.47	6 × 10–3	0.06
	DDX58	Infection	8.46	9.08	0.03	0.02
	OASL	Infection	8.30	4.37	0.13	0.05
	CXCL10	Infection	37.82	11.90	9 × 10–3	0.04
	USP41		1738.34	16.86	< 1 × 10–4	0.06

*Cell type proxy genes identified by Zhernakova et al.¹⁶ or viral infection signature genes identified by Zaas et al.¹⁷ Differential Connectivity was calculated by dividing connectivity in cases by controls and significance was calculated by permutations.