Fig. 5.

Proteome analyses indicate altered protein levels of lysosome pathways in protective phenotype. a Unsupervised clustering of the significantly altered proteome (log2FC) group clusters correctly based on inhibitor and inhibitor target except for SB202190, which is grouped alone. b High sample correlation (PCC) within inhibitor treatment confirms reproducibility, while clusters are also observed within inhibitors with the same molecular target. c The overlap among the significantly altered proteins of samples treated with inhibitors of the same target is 27.7% and 46.4% for p38 MAPK and PKC, respectively, indicating dissimilar effects of the inhibitors. d KEGG pathway analysis reveals downregulation (red) of protein levels within neurodegeneration related KEGG pathways for 3 of 5 compounds. However, lysosome-related pathways show enrichment (green) for 4 of 4 inhibitors with protective phenotype. e GO: biological processes remain devoid of alterations matching the observed protective phenotype