Fig. 2.

Schematic representation of the predicted drug-disease ALS network. This sketch shows the high-confidence predicted drug-disease associations (p value < 0.07) connecting ALS with 121 FDA-approved non-ALS drugs showing a GSEA score > 0. Drugs are colored according to their targeting of receptor/enzyme classes reported in the legend. The edge color indicates the adjusted similarity increasing from red to violet. The different edge line types correspond to different GSEA scores ranging from 1 (dashed lines) to 3 (solid line). Note that the p value threshold of 0.07 allowed us to include some promising histaminergic compounds such as mianserin, showing a borderline p value of 0.06