Table 1.
Homologies between TSH-R and proteins from brain or central nervous system.
| Protein [Entrez Protein GI accession number] | Protein segment | TSH-R segment | Identity | Overall homology* | E value | Coincidences with** | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) [157694513] | 20–253 | 20–252 | 24% | 39% | 1.19 × 10−4 | Eno | D | |
| 177–815 | 52–692 | 24% | 44% | 6.95 × 10−45 | Eno | A | D | ||
| 2 | Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) [4504379] | 234–868 | 32–732 | 24% | 42% | 1.25 × 10−43 | Eno | A | D |
| 3 | Relaxin receptor 2/Leucine-rich repeat-containing G-protein coupled receptor 8 (LGR8) [18677729] | 115–708 | 29–695 | 22% | 40% | 7.82 × 10−29 | Eno | A | D |
| 4 | Relaxin receptor 1/Leucine-rich repeat-containing G protein-coupled receptor 7 (LGR7) [359279868] | 182–738 | 182–710 | 25% | 44% | 1.75 × 10−34 | Eno | A | D |
| 5 | Chondroadherin [153251229] | 24–219 | 28–250 | 21% | 44% | 0.013 | Eno | D | |
| 6 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor (LINGO2) [22749183] | 26–205 | 22–254 | 25% | 43% | 0.028 | Eno | D | |
| 7 | Somatostatin receptor type 2 [4557859] | 24–322 | 395–688 | 23% | 41% | 1.14 × 10−9 | Eno | A | |
| 8 | Neuropeptide Y receptor type 1 [4505445] | 50–331 | 424–689 | 24% | 41% | 2.07 × 10−8 | Eno | A | |
| 9 | Apelin receptor [4885057] | 38–318 | 424–687 | 25% | 42% | 2.78 × 10−8 | Eno | A | |
| 10 | Neuromedin-K receptor/Neurokinin B receptor/Tachykinin receptor 3 [7669548] | 84–382 | 418–696 | 26% | 43% | 4.26 × 10−8 | Eno | A | |
| 11 | Free fatty acid receptor 3 [4885329] | 88–334 | 494–731 | 20% | 41% | 5.11 × 10−7 | Eno | A | |
| 12 | Melanopsin/Opsin-4 [15150803] | 73–386 | 417–710 | 22% | 36% | 1.60 × 10−6 | Eno | A | |
| 13 | G-protein coupled estrogen receptor 1/Membrane estrogen receptor [4504091] | 68–332 | 423–686 | 23% | 41% | 5.02 × 10−6 | Eno | A | |
| 14 | Alpha-1A adrenergic receptor [111118992] | 9–354 | 393–706 | 20% | 38% | 1.71 × 10−5 | Eno | A | |
| 15 | Vasopressin V1a receptor [4502331] | 64–358 | 427–688 | 21% | 39% | 3.46 × 10−5 | Eno | A | |
| 16 | Probable G-protein coupled receptor 34 [4885319] | 26–367 | 370–727 | 19% | 40% | 3.86 × 10−5 | Eno | A | |
| 17 | G-protein coupled receptor 26 [23592220] | 79–200 | 494–609 | 26% | 47% | 7.64 × 10−5 | Eno | A | |
| 18 | Orexin 2 receptor [1285033761] | 71–163 | 424–523 | 28% | 50% | 8.46 × 10−5 | |||
| 19 | Oxytocin receptor [32307152] | 56–357 | 431–711 | 23% | 40% | 1.28 × 10−4 | Eno | A | |
| 20 | Orexin receptor type 1 [222080095] | 63–169 | 431–546 | 28% | 44% | 4.14 × 10−4 | |||
| 21 | Galanin receptor type 2 [4503905] | 37–302 | 426–688 | 22% | 39% | 6.07 × 10−4 | Eno | A | |
| 22 | GPER protein [52350636] | 68–274 | 423–639 | 24% | 42% | 6.90 × 10−4 | Eno | A | |
| 23 | N/OFQ opioid receptor [385252102] | 135–401 | 424–686 | 22% | 41% | 0.002 | Eno | A | |
| 24 | Type 2 angiotensin II receptor [23238240] | 103–350 | 481–707 | 24% | 41% | 0.002 | Eno | A | |
| 25 | Alpha-1B adrenergic receptor [4501959] | 57–357 | 426–687 | 19% | 37% | 0.006 | Eno | A | |
| 26 | Mu opioid receptor [119568090] | 142–453 | 424–744 | 20% | 39% | 0.011 | Eno | A | |
| 27 | Melanin-concentrating hormone receptor 1 [397487122] | 119–393 | 424–691 | 22% | 40% | 0.013 | Eno | A | |
| 28 | Bombesin receptor subtype-3 [4502455] | 60–339 | 427–687 | 19% | 40% | 0.023 | Eno | A | |
| 29 | Neuropeptide Y receptor type 5 [5453796] | 5–93 | 381–466 | 27% | 50% | 0.029 | A | ||
| 30 | C3a anaphylatoxin chemotactic receptor [4757888] | 331–444 | 576–687 | 22% | 44% | 0.151 | A | ||
| 31 | Substance-P receptor/Tachykinin receptor 1 [4507343] | 54–163 | 436–554 | 25% | 41% | 0.365 | |||
| 32 | Proteinase-activated receptor 2 [34577052] | 77–352 | 416–686 | 21% | 39% | 0.394 | Eno | A | |
| 33 | Trace amine-associated receptor 6 (TaR-6) [28173558] | 35–135 | 417–524 | 30% | 53% | 0.463 | |||
| 34 | Urotensin-2 receptor/G-protein coupled receptor 14 [9506745] | 115–323 | 487–686 | 23% | 42% | 0.515 | Eno | A | |
| 35 | Nociceptin receptor [974065167] | 132–322 | 508–686 | 25% | 44% | 0.779 | Eno | A | |
| 36 | G-protein coupled receptor 24 [56554976] | 149–267 | 584–691 | 24% | 47% | 0.812 | A | ||
| 37 | C–C chemokine receptor type 7/Epstein-Barr virus-induced G-protein coupled receptor 1/MIP-3 beta receptor [4502641] | 320–374 | 672–725 | 29% | 49% | 0.941 | |||
| 38 | Olfactory receptor 2A14 [48717236] | 96–164 | 494–562 | 30% | 47% | 1.001 | |||
| 39 | Vasopressin V2 receptor [4557345] | 267–326 | 620–679 | 30% | 45% | 1.119 | A | ||
| 40 | Neuropeptide S receptor [46395496] | 54–336 | 419–684 | 21% | 42% | 1.139 | Eno | A | |
| 41 | Trace amine-associated receptor 8 (TaR-8) [16751917] | 40–100 | 423–483 | 38% | 60% | 1.342 | |||
| 42 | Neuropeptides B/W receptor type 2 [30581164] | 58–326 | 427–688 | 24% | 41% | 2.476 | Eno | A | |
| 43 | Olfactory receptor 2 J3 [185134902] | 39–156 | 426–550 | 24% | 44% | 2.929 | |||
| 44 | G protein-coupled receptor [953233] | 299–318 | 670–689 | 55% | 75% | 7.670 | |||
| 45 | Oxoglutarate (alpha-ketoglutarate) receptor 1 [52426789] | 18–313 | 402–689 | 23% | 38% | 7.822 | Eno | A | |
| 46 | 5-hydroxytryptamine receptor 7 (5-HT7) [10880129] | 111–389 | 445–683 | 20% | 36% | 8.232 | Eno | A | |
*Identical plus similar amino acids.
**Coincidences with segments of TSH-R homologous to known autoantigens of Hashimoto’s encephalopathy, i.e. alpha-enolase (Eno), AKRIAI (A) and DDAHI (D). Segments 149–161 and 560–575 of TSH-R are homologous to segments 40–52 and 284–299 of alpha-enolase, respectively. Segments 360–415, 396–402, 555–563 and 620–676 of TSH-R are homologous to segments 89–141, 258–264, 14–22, and 268–325 of AKRIAI, respectively. Segments 141–148 and 263–292 of TSH-R are homologous to segments 242–249 and 258–283 of DDAHI, respectively [25].