Table 2.
Homologies between thyroglobulin (Tg) and proteins from brain or central nervous system.
| Protein [Entrez Protein GI accession number] | Protein segment | Tgs egment |
Identity | Overall homology* | E value | Coincidences with** | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 | Nidogen-1/Entactin [115298674] | 847–919 | 660–726 | 35% | 52% | 1.23 × 10−5 | |||
| 849–917 | 96–161 | 39% | 50% | 1.61 × 10−5 | |||||
| 859–922 | 1015–1076 | 43% | 58% | 8.51 × 10−7 | |||||
| 867–925 | 1159–1216 | 45% | 53% | 4.60 × 10−4 | Eno | ||||
| 874–919 | 315–358 | 45% | 58% | 0.002 | |||||
| 880–919 | 882–921 | 35% | 52% | 0.281 | |||||
| 2 | Testican-1/Protein SPOCK [4759164] | 281–368 | 972–1062 | 29% | 46% | 6.03 × 10−5 | |||
| 312–385 | 298–367 | 37% | 52% | 2.42 × 10−5 | Eno | ||||
| 313–372 | 96–155 | 35% | 51% | 0.001 | |||||
| 333–372 | 616–653 | 50% | 67% | 7.80 × 10−5 | |||||
| 333–376 | 48–92 | 40% | 62% | 0.001 | |||||
| 3 | Testican-2/SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2 (SPOCK2) [7662036] | 312–374 | 33–89 | 39% | 52% | 3.23 × 10−4 | A | ||
| 325–376 | 1019–1073 | 36% | 54% | 0.017 | |||||
| 327–377 | 1160–1211 | 47% | 64% | 6.91 × 10−5 | Eno | ||||
| 332–376 | 615–658 | 47% | 63% | 2.19 × 10−4 | |||||
| 333–374 | 116–157 | 45% | 59% | 1.94 × 10−4 | |||||
| 333–374 | 315–355 | 50% | 66% | 5.24 × 10−5 | |||||
| 4 | SPARC-related modular calcium-binding protein 1/ Secreted modular calcium-binding protein 1 (SMOC-1) [11545873] | 54–149 | 50–151 | 28% | 40% | 0.034 | |||
| 54–158 | 1106–1210 | 30% | 39% | 1.39 × 10−4 | Eno | A | |||
| 95–149 | 34–83 | 41% | 54% | 2.69 × 10−4 | A | ||||
| 114–294 | 1027–1212 | 28% | 42% | 1.03 × 10−9 | Eno | A | |||
| 116–292 | 181–358 | 25% | 39% | 8.360 | Eno | ||||
| 119–317 | 881–1110 | 26% | 38% | 1.73 × 10−6 | A | ||||
| 227–272 | 34–73 | 30% | 52% | 6.927 | A | ||||
| 227–340 | 96–212 | 26% | 39% | 0.221 | |||||
| 239–295 | 609–661 | 40% | 54% | 0.031 | |||||
| 5 | Testican-3 [3581970] | 300–384 | 17–95 | 31% | 43% | 2.80 × 10−4 | Eno | ||
| 311–373 | 652–717 | 30% | 52% | 0.029 | |||||
| 317–376 | 96–155 | 38% | 46% | 9.63 × 10−4 | |||||
| 318–372 | 999–1062 | 42% | 51% | 1.42 × 10−5 | |||||
| 337–376 | 315–353 | 45% | 57% | 0.018 | |||||
| 337–376 | 616–653 | 42% | 62% | 0.005 | |||||
| 337–376 | 1165–1205 | 48% | 60% | 5.46 × 10−4 | Eno | ||||
| 6 | SPARC-related modular calcium-binding protein 2/ Secreted modular calcium-binding protein 2 (SMOC-2) [262050673] | 91–154 | 598–659 | 34% | 56% | 1.05 × 10−5 | |||
| 105–153 | 311–358 | 36% | 51% | 0.043 | |||||
| 109–156 | 116–163 | 39% | 52% | 0.002 | |||||
| 109–251 | 48–194 | 25% | 40% | 0.017 | |||||
| 109–301 | 1027–1230 | 28% | 43% | 4.21 × 10−13 | A | ||||
| 198–327 | 78–210 | 26% | 40% | 0.030 | |||||
| 233–295 | 613–672 | 33% | 50% | 0.012 | |||||
| 7 | Insulin-like growth factor-binding protein 5 [10834982] | 210–265 | 611–660 | 33% | 51% | 0.033 | |||
| 215–253 | 315–348 | 41% | 56% | 0.581 | |||||
| 8 | Signal peptide, CUB and EGF-like domain-containing protein 1 [120587029] | 636–752 | 1427–1532 | 29% | 36% | 0.106 | |||
| 9 | Ephrin type-B receptor 2 [822606583] | 269–312 | 1473–1531 | 35% | 44% | 2.342 | |||
| 10 | Ephrin type-B receptor 6 [294862532] | 311–335 | 1470–1494 | 48% | 60% | 6.469 | |||
| 11 | Ephrin type-A receptor 7 [568599847] | 260–319 | 1457–1531 | 28% | 42% | 7.379 | |||
| 12 | Acetylcholinesterase (Yt blood group) [219518823] | 46–573 | 2211–2728 | 32% | 50% | 4.79 × 10−66 | A | D | |
| 13 | Butyrylcholinesterase [1073548962] | 9–527 | 2204–2722 | 29% | 47% | 2.43 × 10−61 | A | D | |
| 14 | Neuroligin-3 [262359974] | 66–596 | 2225–2730 | 30% | 46% | 1.36 × 10−52 | A | D | |
| 15 | Neuroligin-4, X-linked [24308209] | 70–539 | 2225–2671 | 29% | 48% | 2.60 × 10−51 | A | D | |
| 16 | Neuroligin-4, Y-linked [256222771] | 70–539 | 2225–2671 | 29% | 48% | 2.98 × 10−51 | A | D | |
| 17 | Neuroligin-1 [1478051093] | 77–546 | 2225–2671 | 31% | 48% | 1.49 × 10−49 | A | D | |
| 18 | Carboxylesterase 3 (CES3) [297747275] | 38–550 | 2204–2724 | 31% | 44% | 3.73 × 10−49 | A | D | |
| 19 | Cocaine esterase [1463570077] | 35–526 | 2204–2722 | 29% | 45% | 2.57 × 10−47 | A | D | |
| 20 | Carboxylesterase 5A [298231153] | 83–580 | 2225–2730 | 28% | 44% | 1.93 × 10−42 | A | D | |
| 21 | Neuroligin-2 [30840978] | 66–550 | 2225–2671 | 28% | 43% | 7.69 × 10−42 | A | D | |
| 22 | Brain carboxylesterase hBr3 [6009628] | 21–549 | 2197–2720 | 28% | 44% | 2.70 × 10−40 | A | D | |
| 23 | Liver carboxylesterase 1/Acyl-coenzyme A:cholesterol acyltransferase/Brain carboxylesterase hBr1/Cocaine carboxylesterase/Egasyn/Methylumbelliferyl-acetate deacetylase 1/Monocyte/macrophage serine esterase/Retinyl ester hydrolase/Serine esterase 1/Triacylglycerol hydrolase [68508965] | 21–552 | 2197–2723 | 28% | 43% | 9.33 × 10−40 | A | D | |
| 24 | KIAA1480 protein, partial [7959221] | 36–470 | 2298–2730 | 28% | 46% | 8.41 × 10−39 | A | D | |
| 25 | Carboxylesterase 4A [1419235141] | 30–509 | 2203–2669 | 29% | 44% | 4.62 × 10−37 | A | D | |
| 26 | Carboxylesterase 8 (CES8) [40555853] | 34–390 | 2318–2669 | 28% | 44% | 5.22 × 10−24 | A | D | |
| 27 | KIAA1366 protein, partial [7243113] | 1–265 | 2409–2671 | 22% | 39% | 0.002 | A | D | |
*Identical plus similar amino acids.
**Coincidences with segments of Tg homologous to known autoantigens of Hashimoto’s encephalopathy, i.e. alpha-enolase (Eno), AKRIAI (A) and DDAHI (D). Segments 298–329, 1171–1186, 1315–1337 and 1368–1385 of Tg are homologous to segments 18–48, 208–223, 375–395 and 280–297 of alpha-enolase, respectively. Segments 31–90, 1086–1114, 1107–1129 and 2612–2668 of Tg are homologous to segments 178–227, 111–140, 6–26 and 86–124 of AKRIAI, respectively. Segments 1597–1612, 2277–2286 and 2605–2617 of Tg are homologous to segments 64–81, 218–227 and 230–242 of DDAHI, respectively [25].