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. 2021 Nov 6;26:100274. doi: 10.1016/j.jcte.2021.100274

Table 3.

Homologies between thyroid peroxidase (TPO) and proteins from brain or central nervous system.

Protein [Entrez Protein GI accession number] Protein segment TPO segment Identity Overall homology* E value Coincidences with**
1 Peroxidasin homolog/Melanoma-associated antigen MG50/Vascular peroxidase 1 [109150416] 604–1314 8–734 41% 58% 1.89 × 10−175 Eno A D
2 Peroxidasin-like protein [633365073] 516–1201 40–734 38% 55% 5.01 × 10−150 Eno A D
3 Prostaglandin G/H synthase 2/Cyclooxygenase-2 [4506265] 208–340 318–459 28% 43% 1.50 × 10−8 A
4 Prostaglandin G/H synthase 1/Cyclooxygenase-1 [18104967] 227–518 324–650 22% 40% 1.35 × 10−5 Eno A D
5 Fibrillin-1/Asprosin/Epididymis secretory sperm binding protein [311033452] 515–572 768–840 32% 47% 0.011
570–613 794–840 36% 55% 0.129
611–655 794–841 43% 56% 3.33 × 10−4
723–765 796–840 37% 55% 0.015
908–952 794–840 36% 51% 0.063
1024–1070 792–840 38% 48% 0.005
1068–1104 794–832 38% 51% 1.620
1174–1238 774–840 29% 46% 1.196
1216–1280 775–840 33% 52% 9.48 × 10−4
1344–1404 776–840 38% 55% 4.31 × 10−5
1392–1455 784–847 27% 50% 0.635
1645–1692 793–843 35% 45% 0.166
1888–1930 793–840 37% 50% 2.828
1928–1973 794–840 53% 63% 8.86 × 10−7
1973–2055 752–840 31% 47% 2.29 × 10−5
2129–2199 740–832 30% 45% 0.005
2244–2291 793–840 37% 52% 2.02 × 10−4
2289–2334 794–841 33% 47% 0.546
2413–2507 768–862 34% 46% 3.61 × 10−5
2522–2567 794–840 36% 46% 0.340
2575–2648 766–840 30% 47% 5.324
2646–2678 794–829 47% 58% 0.198
6 Adhesion G protein-coupled receptor E2/EGF-like module receptor 2/CD312 [23397681] 65–101 794–830 40% 59% 0.030
158–191 791–825 54% 62% 1.82 × 10−4
209–240 793–825 45% 63% 0.155
7 Protocadherin Fat 4 [165932370] 3799–3897 746–838 34% 41% 3.33 × 10−4
8 Low-density lipoprotein receptor-related protein 4 (LRP-4) [157384998] 359–433 747–838 33% 46% 4.08 × 10−4
9 Latent-transforming growth factor beta-binding protein 4 (LTBP4) [110347431] 355–397 794–839 36% 54% 0.431
585–636 794–847 38% 50% 0.506
627–671 794–840 42% 51% 1.506
750–794 794–840 44% 59% 0.064
872–920 790–840 43% 50% 0.023
1047–1091 794–840 51% 61% 5.63 × 10−4
1539–1604 764–825 37% 55% 1.419
10 Fibrillin-3 [56237021] 487–557 794–866 36% 46% 0.004
570–614 794–841 39% 54% 0.174
681–724 795–840 39% 56% 0.323
763–816 793–852 35% 46% 5.987
867–911 794–840 44% 53% 0.396
982–1028 792–840 42% 44% 0.874
1153–1196 794–840 38% 48% 1.322
1169–1238 770–840 35% 47% 0.074
1443–1487 794–841 41% 52% 0.992
1884–1930 794–841 43% 52% 0.041
1959–2012 786–841 35% 51% 0.217
2083–2148 795–862 35% 45% 0.196
2204–2236 793–825 50% 64% 1.605
2368–2468 762–862 31% 42% 0.001
2483–2528 794–840 41% 50% 5.275
2536–2601 766–831 39% 52% 0.078
2598–2640 786–829 47% 56% 4.494
11 Latent-transforming growth factor beta-binding protein 1 (LTBP-1) [290457687] 902–979 785–862 28% 42% 0.034
1074–1286 626–840 24% 36% 0.013 Eno
1200–1244 794–840 43% 56% 0.001
1436–1507 768–839 28% 45% 0.440
1621–1706 738–839 29% 36% 2.230
12 Seizure related 6-like protein 2 [608785583] 541–610 736–802 33% 45% 0.003
13 CUB and sushi domain-containing protein 1 [259013213] 1200–1282 739–805 29% 38% 0.968
2478–2555 727–797 34% 48% 0.003
14 C-type lectin domain family 14 member A/Epidermal growth factor receptor 5 (EGFR-5) [28269707] 256–290 808–842 51% 60% 0.004
15 fibrillin 1 variant, partial [62087260] 438–490 786–840 38% 54% 0.005
16 Multiple epidermal growth factor-like domains protein 6 [110347457] 247–324 745–838 34% 45% 0.008
17 Seizure 6-like protein/KIAA0927 protein [296179442] 392–449 741–795 34% 48% 0.009
18 Cadherin EGF LAG seven-pass G-type receptor 2/Cadherin family member 10/Flamingo homolog 3 [13325064] 1296–1351 807–862 40% 50% 0.011
19 Low-density lipoprotein receptor-related protein 2 (LRP-2) [126012573] 1388–1428 794–838 40% 51% 0.386
3136–3191 767–838 31% 44% 0.550
4000–4054 789–845 38% 49% 0.011
20 EGF-containing fibulin-like extracellular matrix protein 2 [14714634] 121–164 794–840 44% 48% 0.272
141–203 772–840 34% 50% 0.012
263–319 776–829 36% 50% 0.120
21 Nephronectin/Preosteoblast EGF-like repeat protein with MAM domain/EGFL6-like [75709198] 212–259 794–847 38% 61% 0.016
22 Complement component C1q receptor/CD93 [88758613] 326–369 766–825 38% 46% 5.378
383–427 794–840 45% 56% 0.016
410–468 767–839 34% 45% 0.367
23 Fibulin 5 [19743803] 113–161 768–831 35% 48% 0.019
24 Tolloid-like protein 1 [22547221] 567–614 789–838 42% 50% 0.020
25 EGF-containing fibulin-like extracellular matrix protein 1 [86788015] 204–254 786–840 38% 52% 0.023
26 Signal peptide, CUB and EGF-like domain-containing protein 1 [120587029] 64–117 786–840 29% 49% 1.882
270–323 786–840 42% 50% 0.023
360–407 794–844 33% 56% 3.772
27 Latent-transforming growth factor beta-binding protein 1 (LTBP1) [219518146] 576–665 785–881 26% 40% 0.032
28 KIAA1237 protein, partial [34327974] 912–944 796–831 47% 58% 0.040
29 Vitamin K-dependent protein S [192447438] 137–201 776–840 32% 50% 0.041
30 Protein HEG homolog 1 [153792110] 1025–1057 796–831 47% 58% 0.047
31 Low-density lipoprotein receptor-related protein 1B (LRP-1B) [93102379] 96–155 793–840 28% 41% 5.824
104–193 745–838 28% 45% 0.049
2909–2968 793–840 31% 50% 0.817
2966–3002 794–834 46% 63% 0.081
32 P-selectin (CD62P)/Granule membrane protein 140/Leukocyte-endothelial cell adhesion molecule 3/Platelet activation dependent granule-external membrane protein [215274139] 531–621 759–843 31% 47% 0.053
33 Fibulin-1 (FIBL-1) [215274249] 475–552 752–824 31% 46% 0.065
34 Fibulin 1 [18490682] 189–257 755–834 35% 45% 0.257
354–405 794–846 41% 47% 0.066
390–441 787–840 37% 51% 0.404
35 Protein kinase C-binding protein NELL2 [223029476] 461–500 794–834 43% 58% 0.067
36 NOTCH4 protein [187954607] 192–230 795–838 43% 50% 6.636
272–342 756–825 32% 46% 0.077
37 complement receptor type 2 [54792123] 398–467 731–795 33% 43% 2.909
935–970 764–798 50% 58% 0.103
38 dual oxidase 2 precursor variant, partial [62087600] 59–106 650–695 33% 60% 0.113
39 Nidogen-1/Entactin [115298674] 800–840 794–839 43% 50% 0.132
40 CSMD2 protein [62954774] 2404–2593 627–802 25% 38% 0.135 Eno
41 Cysteine-rich with EGF-like Domains 2 (CRELD2) beta [67511376] 202–266 767–839 35% 45% 0.135
42 Endosialin/CD248 [9966885] 283–356 755–844 26% 38% 0.203
43 Epidermal growth factor-like protein 7 [7705889] 137–185 796–847 40% 50% 0.208
44 Prolow-density lipoprotein receptor-related protein 1/ Alpha-2-macroglobulin receptor/Apolipoprotein E receptor/CD91 [126012562] 148–188 794–838 42% 53% 2.343
2941–3012 797–863 35% 43% 0.251
45 CUB and sushi domain-containing protein 3 [38045888] 2874–2939 741–806 34% 44% 0.260
46 Thrombospondin-3 [6005902] 367–397 793–823 41% 64% 0.268
47 Epidermal growth factor-like protein 6 [13124888] 93–135 795–841 42% 53% 1.360
217–252 794–830 43% 56% 0.270
48 Mutant p53 binding protein 1 variant, partial [62087822] 254–293 796–840 35% 53% 0.782

*Identical plus similar amino acids.

**Coincidences with segments of TPO homologous to known autoantigens of Hashimoto’s encephalopathy, i.e. alpha-enolase (Eno), AKRIAI (A) and DDAHI (D). Segments 603–627, 609–623, 637–659, 700–722, 710–721 of TPO are homologous to segments 261–281, 227–241, 211–233, 243–265, 346–357 of alpha-enolase, respectively. Segments 333–369, 410–456, 421–428 and 535–552 of TPO are homologous to segments 282–324, 22–72, 289–296 and 169–186 of AKRIAI, respectively. Segment 492–566 of TPO is homologous to segment 10–77 of DDAHI [25].