Table 2.

circRNA-miRNA-mRNA interaction network

Name of the circular RNA	Target miRNA	Target mRNA	Study model	Diabetic complication	Outcome	Reference
CDR1as ↑	miR-7↓	Myrip and Pax6 ↑	MIN6 cells (rat islet cells)	diabetes	affected insulin secretion	49
circHIPK3 ↑	miR-124-3p and miR-338-3p↓	Slc2a2, Akt1, and Mtpn ↑	human islets, MIN6B1 cells (rat islet cells)	diabetes	regulated essential β cell activities, altered expression in diabetes models	68
circRNA15698 ↑	miR-185 ↓	Tgf-β1 ↑	diabetic mice C57BL/KsJ-db/db	diabetic nephropathy	promoted ECM-related protein synthesis	69
circWDR77 ↑	miR-124 ↓	Fgf-2 ↑	human VSMCs and HEK 293T cells	diabetic cardiomyopathy	suppressed VSMC proliferation and migration	70
circRNA000203 ↑	miR-26b-5p ↓	Col1a2, Col3a1, and α-SMA ↑	diabetic db/db mice, C57BL/6 mice	diabetic cardiomyopathy	the enhanced fibrotic phenotype in cardiac fibroblasts	71
CACR ↑	miR-214-3p ↓	Caspase 1 ↑	human cardiomyocyte AC16 cells	diabetic cardiomyopathy	alleviated pyroptosis in cardiomyocytes	72
circRNA010567 ↑	miR-141 ↓	Tgf-β1 ↑	diabetic db/db mice, C57BL/6 mice	diabetic cardiomyopathy	suppressed fibrosis-associated protein resection in CFs	12
circHIPK3 ↑	miR-30a-3p ↓	Vegf-c, Fzd4, and Wnt2 ↑	C57BL/6 mice	DR	altered retinal endothelial cell function and microvascular dysfunction	73
circ0005015 ↑	miR-519d-3p ↓	Mmp2, Xiap and Stat3 ↑	HRVECs	DR	facilitated retinal endothelial angiogenic function	74
circDNMT3B ↓	miR-20b-5p ↑	Bambi ↓	Sprague-Dawley rats, HRMECs	DR	reduced retinal acellular capillary number and alleviated visual damage	75
CPWWP2A ↑	miR-579 ↓	Ang 1, Occludin, and Sirt1 ↑	C57BL/6 mice, HRVECs and human retinal pericytes	DR	affected retinal vascular dysfunction	76
CZNF609 ↑	miR-615-5p ↓	Mef2A ↑	Human umbilical vein endothelial cells (HUVECs), C57BL/6 mice	DR	increased the migration and tube formation ability of HUVECs, and rescued HUVECs from oxidative stress or hypoxia-induced apoptosis	77