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. 2021 Nov 4;26:1280–1290. doi: 10.1016/j.omtn.2021.10.029

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Tubule-specific LincRNA-p21 deletion improves kidney histology in HFD-fed mice

(A) PAS staining shows histological changes in LincRNA-p21 KO mice or their CTL littermates fed with ND (KO-ND or CTL-ND) or HFD (KO-HFD, or CTL-HFD) (arrowhead, mesangial expansion; arrow, loss of brush border; star, cytoplasmic vacuolation). (B and C) Quantitative analysis of glomerular tuft area (B) and tubular injury score (C) by PAS staining at age 16 weeks. (D) IHC staining of NGAL in kidney after LincRNA-p21 deletion. (E) Quantitative analysis of NGAL expression by IHC staining in kidneys. (F) Renal cortical expression of NGAL transcripts by qRT-PCR. Data are expressed as mean ± SEM from each group (n ≥ 5); ∗p < 0.05.