Figure 3.

NKG2D CAR-NK cells display antitumor effects in vivo

(A) Schematic diagram of a mouse experiment assessing the antitumor effects of NKG2D CAR-modified NK cells in immune-deficient NSG mice. PBS, mock NK cells, or CAR-NK cells were i.v. injected, followed by i.p. injection of IL-2, n = 5 per group. (B) Bioluminescent images prior to treatment (day 10) and following the treatments on day 21 to day 49. (C) Tumor burden over time by BLI after the treatment. Each mouse is represented by one line. ∗∗∗∗p < 0.0001. (D) Kaplan-Meier analysis of survival. Statistical analysis of survival between groups was performed using the log rank test. MS, median survival time. ∗∗p < 0.01.