Figure 8.

Clinical significance of TFGB3-AS1 in patients with HHcy

(A and B) The serum levels of Hcy, proinflammatory cytokines TNF-α, IL-1β, IL-6, and CRP in healthy individuals and patients with HHcy. n = 50 per group. (C) The expression levels of TGFB3-AS1, miR-144, and Rap1a in peripheral blood monocytes of healthy individuals and patients with HHcy were determined by qRT-PCR. (D and E) Correlations between TFGB3-AS1 expression and serum levels of Hcy or proinflammatory cytokines (IL-6, IL-1β, TNF-α, and CRP) in all enrolled subjects were evaluated by Pearson correlation analysis. (F) The correlation between TFGB3-AS1 expression and expression of miR-144 or Rap1a in peripheral monocytes of all enrolled subjects. (G) Correlation analysis of miR-144 and Rap1a expression in peripheral monocytes of all enrolled subjects. (H) Correlations between TFGB3-AS1 expression and the serum lipid levels (LDL-C, HDL-C, TG, and CHO) in all enrolled subjects. Pearson correlation coefficients (r) and p values are presented in the graphs. ∗p < 0.05, ∗∗p < 0.01, compared with healthy group.