. 2021 Nov 1;118(45):e2111863118. doi: 10.1073/pnas.2111863118

Table 2.

Statistics for principal component analyses

Data type	Principal component	Tissue category	n	Average coefficient	KS D statistic	KS critical value	WMW U statistic	WMW P value	WTT ν	WTT t statistic	WTT P value
2D ¹³C-¹³C Aβ40	1	RADC	8	0.192 (0.031)
2D ¹³C-¹³C Aβ40	1	t-AD	11	0.182 (0.035)	0.318^†	0.637^†	53^†	0.467^†	16.09^†	0.623^†	0.542^†
2D ¹³C-¹³C Aβ40	1	PCA-AD	9	0.184 (0.042)	0.222^†	0.663^†	37^†	0.925^†	14.61^†	0.435^†	0.670^†
2D ¹³C-¹³C Aβ40	1	t-AD + PCA-AD	20	0.183 (0.037)	0.200^†	0.579^†	90^†	0.618^†	15.29^†	0.630^†	0.538^†
2D ¹³C-¹³C Aβ40	2	RADC	8	−0.225 (0.197)
2D ¹³C-¹³C Aβ40	2	t-AD	11	0.061 (0.094)	0.750^*	0.637^*	11^*	0.004^*	9.34^*	–3.804^*	0.004^*
2D ¹³C-¹³C Aβ40	2	PCA-AD	9	0.131 (0.071)	0.875^*	0.663^*	4^*	0.001^*	8.613^*	–4.843^*	0.001^*
2D ¹³C-¹³C Aβ40	2	t-AD + PCA-AD	20	0.093 (0.090)	0.750^*	0.579^*	15^*	<0.001^*	8.193^*	–4.383^*	0.002^*
2D ¹³C-¹³C Aβ40	3	RADC	8	−0.086 (0.263)
2D ¹³C-¹³C Aβ40	3	t-AD	11	0.036 (0.148)	0.409^†	0.637^†	34^†	0.418^†	10.217^†	–1.183^†	0.264^†
2D ¹³C-¹³C Aβ40	3	PCA-AD	9	0.082 (0.143)	0.500^†	0.663^†	16^†	0.053^†	10.539^†	–1.607^†	0.138^†
2D ¹³C-¹³C Aβ40	3	t-AD + PCA-AD	20	0.057 (0.144)	0.45^†	0.579^†	50^†	0.129^†	8.732^†	–1.450^†	0.182^†
2D ¹⁵N-¹³C Aβ40	1	RADC	8	0.197 (0.023)
2D ¹⁵N-¹³C Aβ40	1	t-AD	11	0.198 (0.029)	0.284^†	0.637^†	43^†	0.936^†	16.909^†	–0.104^†	0.918^†
2D ¹⁵N-¹³C Aβ40	1	PCA-AD	6	0.199 (0.038)	0.333^†	0.729^†	21^†	0.708^†	7.621^†	–0.115^†	0.911^†
2D ¹⁵N-¹³C Aβ40	1	t-AD + PCA-AD	17	0.199 (0.031)	0.199^†	0.592^†	64^†	0.820^†	18.784^†	–0.137^†	0.893^†
2D ¹⁵N-¹³C Aβ40	2	RADC	8	−0.134 (0.198)
2D ¹⁵N-¹³C Aβ40	2	t-AD	11	0.093 (0.201)	0.568^†	0.637^†	18^*	0.029^*	15.374^*	–2.467^*	0.026^*
2D ¹⁵N-¹³C Aβ40	2	PCA-AD	6	0.070 (0.102)	0.625^†	0.729^†	10^†	0.070^†	10.911^*	–2.516^*	0.029^*
2D ¹⁵N-¹³C Aβ40	2	t-AD + PCA-AD	17	0.085 (0.169)	0.574^†	0.592^†	28^*	0.017^*	12.013^*	–2.712^*	0.019^*
2D ¹⁵N-¹³C Aβ40	3	RADC	8	−0.092 (0.173)
2D ¹⁵N-¹³C Aβ40	3	t-AD	11	0.030 (0.246)	0.364^†	0.637^†	28^†	0.191^†	16.996^†	–1.275^†	0.219^†
2D ¹⁵N-¹³C Aβ40	3	PCA-AD	6	0.028 (0.144)	0.458^†	0.729^†	15^†	0.255^†	11.812^†	–1.427^†	0.180^†
2D ¹⁵N-¹³C Aβ40	3	t-AD + PCA-AD	17	0.030 (0.210)	0.390^†	0.592^†	43^†	0.148^†	16.617^†	–1.531^†	0.144^†
2D ¹³C-¹³C Aβ42	1	RADC	8	−0.233 (0.023)
2D ¹³C-¹³C Aβ42	1	t-AD	7	−0.193 (0.021)	0.857^*	0.702^*	5^*	0.005^*	12.947^*	–3.511^*	0.004^*
2D ¹³C-¹³C Aβ42	1	PCA-AD	7	−0.204 (0.025)	0.607^†	0.702^†	10^*	0.034^*	12.229^*	–2.296^*	0.040^*
2D ¹³C-¹³C Aβ42	1	t-AD + PCA-AD	14	−0.199 (0.023)	0.714^*	0.610^*	15^*	0.003^*	14.881^*	–3.374^*	0.004^*
2D ¹³C-¹³C Aβ42	2	RADC	8	0.186 (0.130)
2D ¹³C-¹³C Aβ42	2	t-AD	7	−0.197 (0.205)	0.875^*	0.702^*	54^*	0.001^*	9.933^*	4.255^*	0.002^*
2D ¹³C-¹³C Aβ42	2	PCA-AD	7	−0.044 (0.106)	0.875^*	0.702^*	51^*	0.005^*	12.951^*	3.766^*	0.002^*
2D ¹³C-¹³C Aβ42	2	t-AD + PCA-AD	14	−0.121 (0.176)	0.875^*	0.610^*	105^*	<0.001^*	18.408^*	4.661^*	<0.001^*
2D ¹³C-¹³C Aβ42	3	RADC	8	−0.075 (0.326)
2D ¹³C-¹³C Aβ42	3	t-AD	7	−0.007 (0.113)	0.375^†	0.702^†	27^†	0.911^†	8.843^†	–0.547^†	0.598^†
2D ¹³C-¹³C Aβ42	3	PCA-AD	7	0.107 (0.095)	0.500^†	0.702^†	19^†	0.308^†	8.334^†	–1.505^†	0.169^†
2D ¹³C-¹³C Aβ42	3	t-AD + PCA-AD	14	−0.050 (0.116)	0.375^†	0.610^†	46^†	0.504^†	8.033^†	–1.043^†	0.328^†
2D ¹⁵N-¹³C Aβ42	1	RADC	8	−0.220 (0.017)
2D ¹⁵N-¹³C Aβ42	1	t-AD	7	−0.241 (0.037)	0.589^†	0.702^†	39^†	0.210^†	8.241^†	1.333^†	0.218^†
2D ¹⁵N-¹³C Aβ42	1	PCA-AD	4	−0.220 (0.028)	0.375^†	0.813^†	17^†	0.871^†	4.185^†	–0.039^†	0.970^†
2D ¹⁵N-¹³C Aβ42	1	t-AD + PCA-AD	11	−0.233 (0.034)	0.420^†	0.637^†	56^†	0.330^†	15.512^†	1.063^†	0.304^†
2D ¹⁵N-¹³C Aβ42	2	RADC	8	0.197 (0.067)
2D ¹⁵N-¹³C Aβ42	2	t-AD	7	−0.185 (0.229)	1.000^*	0.702^*	56^*	<0.001^*	6.897^*	4.263^*	0.004^*
2D ¹⁵N-¹³C Aβ42	2	PCA-AD	4	0.030 (0.180)	0.750^†	0.813^†	27^†	0.060^†	3.423^†	1.801^†	0.158^†
2D ¹⁵N-¹³C Aβ42	2	t-AD + PCA-AD	11	−0.107 (0.230)	0.909^*	0.637^*	83^*	<0.001^*	12.225^*	4.151^*	0.001^*
2D ¹⁵N-¹³C Aβ42	3	RADC	8	−0.070 (0.358)
2D ¹⁵N-¹³C Aβ42	3	t-AD	7	0.047 (0.031)	0.625^†	0.702^†	19^†	0.308^†	7.121^†	–0.918^†	0.389^†
2D ¹⁵N-¹³C Aβ42	3	PCA-AD	4	0.100 (0.027)	0.750^†	0.831^†	8^†	0.183^†	7.157^†	–1.328^†	0.225^†
2D ¹⁵N-¹³C Aβ42	3	t-AD + PCA-AD	11	0.066 (0.039)	0.625^†	0.637^†	27^†	0.164^†	7.119^†	–1.068^†	0.321^†

Results from WMW, KS, and WTT tests in t-AD, PCA-AD, and t-AD + PCA-AD rows represent comparisons with principal component coefficients of RADC data.

^*Statistically significant differences from coefficients for RADC samples.

^†An absence of statistical significance.