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Gating pore currents of ASD mutants in KV7Oc. (A) Current-voltage (I-V) curve of KV7Oc/R1C showing inward gating pore current starting from −50 mV carried by Na+ and outward wild-type gating pore current, starting from +50 mV, carried by Cs+. (B and C) I-V curves of outward and inward gating pore current of KV7Oc/R2C carried by Na+. (D) Ion selectivity of the outward gating pore current from KV7Oc/R4C: Na+ (gold), K+ (purple), and Cs+ (red). n = 7 to 10 cells.
