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View full-text article in PMC

. 2021 Nov 2;118(45):e2112666118. doi: 10.1073/pnas.2112666118

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Fig. 3. — Gating pore currents of ASD mutants in hK_V7.3. (A) I-V curves of hK_V7.3/R1Q and hK_V7.3/R2C inward gating pore current carried by K⁺. Voltage onset for hK_V7.3/R1Q is −50 mV, while hK_V7.3/R2C inward gating pore current starts from 0 mV. n = 10 cells. (B) I-V curves of outward gating pore current of hK_V7.3/R1Q and hK_V7.3/R2C carried by K⁺. n = 10 cells. (C) I-V curves of outward current of hK_V7.3/R4C carried by K⁺. hK_V7.3/R4C outward current is carried by leak through the R4C and Q3 positions. n = 9 cells. (D) Comparison of I-V curves of outward gating pore current of hK_V7.3/R2C and hK_V7.3/R4C. hK_V7.3/R2C outward current is carried by leak through both the R2C and Q3 positions, while the hK_V7.3/R4C outward gating pore current is carried by leak through the R4C and Q3 positions.