Table III.
Comparison of immunosenescence markers according to clinical manifestations of systemic lupus erythematosus patients
| Clinical manifestations | CD4+CD57+ | CD8+CD57+ | CD4+KLRG1+ | CD8+KLRG1+ | IFN-γ levels | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Value [%] | p-value | Value [%] | p-value | Value [%] | p-value | Value [%] | p-value | Value [pg/ml] | p-value | |
| Neuropsychiatric | ||||||||||
| Yes | 5.0 (1.9–7.8) | 0.002* | 15.8 ±8.6 | 0.134 | 8.9 (4.9–15.1) | 0.023* | 21.8 ±6.9 | 0.004* | 54.9 (5.4–124.4) | 0.328 |
| No | 0.5 (1.0–2.3) | – | 11.1 ±6.8 | – | 2.8 (1.3–4.9) | – | 12.6 ±6.9 | – | 8.9 (5.–40.7) | – |
| Vasculitis | ||||||||||
| Yes | 1.8 (0.6–4.1) | 0.238 | 14.8 ±6.1 | 0.039* | 3.5 (1.4–8.8) | 0.211 | 15.3 ±5.6 | 0.335 | 9.5 (6.4–101.3) | 0.186 |
| No | 1.1 (0.5–2.6) | – | 10.5 ±7.2 | – | 2.8 (1.2–4.9) | – | 13.1 ±8.1 | – | 8.2 (4.9–44.4) | – |
| Arthritis | ||||||||||
| Yes | 1.3 (0.7–3.3) | 0.282 | 14.2 ±6.8 | 0.077 | 2.4 (1.3–5.4) | 0.523 | 14.1 ±6.7 | 0.771 | 8.9 (5.6–39.3) | 0.812 |
| No | 1.1 (0.4–2.3) | – | 10.5 ±7.0 | – | 3.7 (1.3–5.4) | – | 13.4 ±7.9 | – | 8.4 (5.2–101.3) | – |
| Nephritis | ||||||||||
| Yes | 1.3 (0.7–3.7) | 0.180 | 13.9 ±6.9 | 0.031* | 3.7 (1.6–10.4) | 0.095 | 15.3 ±7.2 | 0.157 | 9.5 (5.7–103.9) | 0.192 |
| No | 1.1 (0.4–1.9) | – | 9.7 ±6.8 | – | 2.4 (1.3–4.8) | – | 12.3 ±7.6 | – | 7.9 (5.2–30.7) | – |
| Mucocutaneous | ||||||||||
| Yes | 1.2 (0.7–2.8) | 0.184 | 13.2 ±7.8 | 0.124 | 4.0 (1.7–8.8) | 0.032* | 15.8 ±7.6 | 0.045* | 9.5 (8.5–101.3) | 0.007* |
| No | 1.0 (0.4–2.2) | – | 10.2 ±6.2 | – | 2.4 (1.0–4.6) | – | 11.7 ±7.1 | – | 6.4 (4.5–17.4) | – |
| Serositis | ||||||||||
| Yes | 1.2 (0.6–3.5) | 0.792 | 11.4 ±6.8 | 0.647 | 4.9 (1.8–12.0) | 0.130 | 14.9 ±8.2 | 0.513 | 39.3 (7.3–123.3) | 0.052 |
| No | 1.2 (0.5–2.8) | – | 12.5 ±8.4 | – | 2.8 (1.3–4.9) | – | 13.3 ±7.4 | – | 8.4 (5.0–30.7) | – |
| Increased anti-dsDNA | ||||||||||
| Yes | 1.2 (0.6–3.2) | 0.282 | 11.5 ±6.9 | 0.802 | 3.7 (1.3–5.9) | 0.154 | 13.6 ±7.7 | 0.885 | 9.5 (5.4–81.2) | 0.064 |
| No | 1.2 (0.5–1.7) | – | 12.1 ±7.8 | – | 2.4 (1.3–3.2) | – | 13.9 ±7.1 | – | 6.3 (5.4–8.2) | – |
| Low Complement | ||||||||||
| Yes | 2.0 (1.2–4.9) | 0.007* | 14.7 ±6.9 | 0.010 | 3.2 (2.4–8.8) | 0.146 | 15.7 ±7.8 | 0.107 | 39.3 (8.2–122.2) | 0.013* |
| No | 0.8 (0.5–1.7) | – | 9.6 ±6.5 | – | 2.3 (1.2–5.1) | – | 12.3 ±7.1 | – | 7.0 (5.1–10.6) | – |
| Thrombocytopenia | ||||||||||
| Yes | 1.2 (0.3–4.9) | 0.858 | 15.7 ±8.4 | 0.235 | 8.0 (2.1–13.6) | 0.387 | 17.0 ±10.8 | 0.357 | 54.9 (6.5–111.8) | 0.547 |
| No | 1.2 (0.6–2.8) | – | 11.3 ±6.9 | – | 2.9 (1.3–5.3) | – | 13.4 ±7.3 | – | 8.9 (5.4–42.0) | – |
| Leukopenia | ||||||||||
| Yes | 1.2 (0.6–4.5) | 0.601 | 13.0 ±6.9 | 0.377 | 3.4 (1.3–10.4) | 0.496 | 12.5 ±7.5 | 0.505 | 9.5 (6.7–101.3) | 0.401 |
| No | 1.2 (0.5–2.8) | – | 11.1 ±7.2 | – | 2.8 (1.3–5.3) | – | 14.1 ±7.6 | – | 8.1 (5.4–42.0) | – |
IFN-γ – interferon γ, KLRG1 – killer cell lectin like receptor G1
*
p < 0.05 considered significant.