TABLE 2.

Metabolomics were undertaken in the plasma of the animals. Different lengths of acylcarnitine species are displayed. Data presented as mean ± SD. Two‐way ANOVA undertaken and the effects of an interaction, STZ and meldonium are displayed with p‐values, where p < 0.05 was considered significant

	Control		STZ		STZ	Meldonium	Interaction
Metabolites [μg/ml]	Saline	Meldonium	Saline	Meldonium	p	p	p
Meldonium	0.54 ± 0.33	40 ± 0.17	0.55 ± 0.17	32 ± 22	0.51	<0.0001	0.51
l‐carnitine	1.11 ± 0.66	0.55 ± 0.14	0.65 ± 0.19	0.32 ± 0.05	0.026	0.0059	0.41
Acetylcarnitine	3.4 ± 1.8	15 ± 21	1.8 ± 0.090	2.8 ± 6.0	0.15	0.18	0.26
C3‐acylcarnitine	0.20 ± 0.057	0.052 ± 0.030	0.12 ± 0.025	0.034 ± 0.034	0.0055	<0.0001	0.061
C5‐acylcarnitine	0.11 ± 0.028	0.11 ± 0.014	0.10 ± 0.019	0.11 ± 0.014	0.29	0.78	0.33
C6‐acylcarnitine	12 ± 2.7	3.6 ± 1.8	5.2 ± 1.4	2.6 ± 2.1	0.0002	<0.0001	0.0027
C14‐acylcarnitine	6.9 ± 3.7	1.4 ± 0.74	3.5 ± 1.4	0.75 ± 0.55	0.022	<0.0001	0.11
C18‐acylcarnitine	2.8 ± 2.5	1.0 ± 0.45	1.7 ± 0.64	1.0 ± 0.75	0.32	0.035	0.35
C18:1‐acylcarnitine	1.4 ± 1.02	0.82 ± 0.43	1.7 ± 0.37	0.67 ± 0.30	0.43	0.040	0.85