TABLE 3.

A Langendorff ischemia/reperfusion protocol was undertaken. The functional parameters obtained before ischemia, during ischemia and after ischemia are displayed. Data presented as mean ± SD. Two‐way ANOVA was undertaken and the effects of an interaction, STZ and meldonium (Mel) are displayed with p‐values, where p < 0.05 was considered significant

	Control		STZ		STZ	Mel	Interaction
	Saline	Meldonium	Saline	Meldonium	p	p	p
Before ischemia
RPP [mm Hg x BPM]	37 000 ± 4000	41 000 ± 11 000	25 000 ± 8000	25 000 ± 10 000	0.0008	0.57	0.57
HR [BPM]	256 ± 25	257 ± 25	221 ± 20	216 ± 31	0.003	0.84	0.75
Developed pressure [mm Hg]	147 ± 20	152 ± 40	112 ± 31	118 ± 48	0.027	0.69	0.94
Systolic pressure [mm Hg]	147 ± 19	151 ± 37	98 ± 60	118 ± 49	0.021	0.48	0.65
Diastolic pressure [mm Hg]	−2.0 ± 13	2.0 ± 7.0	−0.031 ± 5.7	−6.4 ± 19	0.49	0.80	0.27
Ischemia
Systolic pressure [mm Hg]	28 ± 15	29 ± 20	55 ± 25	17 ± 12	0.0039	0.62	0.61
Diastolic pressure [mm Hg]	17 ± 6	14 ± 20	43 ± 32	36 ± 17	0.0046	0.50	0.78
After ischemia
RPP [mm Hg x BPM]	32 000 ± 8000	40 000 ± 13 000	14 000 ± 8000	21 000 ± 7000	<0.0001	0.045	0.82
HR [BPM]	226 ± 19	242 ± 44	198 ± 31	173 ± 22	0.0026	0.77	0.17
Developed pressure [mm Hg]	144 ± 29	158 ± 41	72 ± 39	141 ± 61	0.017	0.025	0.13
Systolic pressure [mm Hg]	174 ± 16	178 ± 27	96 ± 44	163 ± 46	0.0021	0.013	0.029
Diastolic pressure [mm Hg]	25 ± 18	14 ± 27	36 ± 39	−6.4 ± 62	0.76	0.090	0.31