Fig. 8.

Biosafety of GCE/siRNA in vivo. (A) H&E staining of the major organs from mice treated with NS (Control), naked siRNA, GCE/siRNA and DOX. (100 ×). (B) Hemolysis activity of GCE/siRNA, hemolysis rate was evaluated in rat RBC after treatment with naked siRNA, GCE, GCE/siRNA or Lipo/siRNA. The data were presented as the mean ± SD, n = 3. (C) Blood biochemistry data including liver function markers: ALT, AST, ALP, TB and ALB, and kidney function markers: CREA, UA and UREA. The data were presented as the mean ± SD, n = 5.