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Schematic illustration of mechanisms and preparation of GCE/siRNA. (A) GCE/siRNA were prepared by GO-COOH, functionalization with chitosan (GO-CS), immobilization with anti-EpCAM (GCE) and then mixing with survivin-siRNA (GCE/siRNA) in aqueous solution. (B) After targeted into tumor tissues, GCE could deliver survivin-siRNA into cells successfully, and survivin-siRNA could release from GCE/siRNA to perform the antitumor effect.
