Table. Baseline Characteristics of the Cohort.
| Characteristic | Mean (SD) value | P value | ||||
|---|---|---|---|---|---|---|
| DLB (n = 371 [37.6%]) | AD (n = 207 [20.9%]) | PD (n = 204 [20.7%]) | HC (n = 205 [20.8%]) | Total (N = 987) | ||
| Sex, No. (%) | ||||||
| Female | 159 (42.9) | 121 (58.5) | 79 (38.7) | 116 (56.6) | 475 (48.1) | <.001 |
| Male | 212 (57.1) | 86 (41.5) | 125 (61.3) | 89 (43.4) | 512 (51.9) | |
| Age, y | 71.8 (8.0) | 71.7 (8.0) | 69.2 (9.9) | 65.1 (8.0) | 70.0 (8.8) | <.001a,b |
| Years of education | 9.2 (4.2) | 9.0 (4.0) | 9.9 (4.7) | 12.9 (3.6) | 9.79 (4.5) | <.001a |
| Duration of symptoms, moc | 25.2 (30.3) | 25.6 (26.6) | 71.5 (62.9) | 53.6 (61.1) | 41.2 (49.1) | <.001b |
| MMSE score | 21.7 (6.0) | 21.4 (5.3) | 26.9 (3.7) | 28.5 (1.7) | 23.2 (5.8) | <.001a,b |
| Plasma p-tau231 level, pg/mL | 12.8 (6.6) | 16.9 (12.1) | 12.3 (6.8) | 11.0 (6.9) | 13.2 (8.4) | <.001a,d |
| Plasma p-tau181 level, pg/mL | 18.2 (9.5) | 28.7 (28.4) | 17.0 (8.5) | 16.7 (18.5) | 18.1 (17.2) | <.001a,d |
| Abnormal CSF Aβ42 level, No. (%) | 63 (17.0) | 113 (54.6) | NA | NA | NA | NA |
Abbreviations: AD, Alzheimer disease; CSF, cerebrospinal fluid; DLB, dementia with Lewy bodies; HC, healthy control; MMSE, Mini-Mental State Examination; NA, not applicable; PD, Parkinson disease.
a
Differences between DLB and HC.
b
Differences between DLB and PD.
c
Duration from first motor or cognitive symptom.
d
Differences between DLB and AD.