Fig. 2. (A) Schematic of assay for MDM2 detection showing specific interactions between MDM2 and peptide on silver nanoparticle surface, resulting in nanoparticle assembly. (B) Change in extinction after nanoparticle assembly due to aggregation of nanoparticles. (C) Increase in SERS signal after nanoparticle assembly due to formation of hotspots.¹¹⁵.