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. 2021 Nov 9;118(46):e2104721118. doi: 10.1073/pnas.2104721118

Fig. 4.

Fig. 4.

Initiation of ART in AHI prevents the loss of peripheral blood CD4+ iNKT cells. Absolute cell count of peripheral blood iNKT (A), CD4+ iNKT (B), CD4− iNKT (C) cells in HIV-uninfected subjects (HIV-neg black, n = 17), Fiebig I (dark blue), Fiebig II (light blue), and Fiebig III (orange) HIV-infected individuals before (HIV acute, n = 39) and after 24 mo of ART (n = 31). Paired pre- and post-ART absolute CD4+ (D) and CD4− (E) iNKT cell count in study participants that initiated ART in Fiebig stage III (n = 16). Expression of HLA-DR (F), CD38 (G), and TIGIT (H) by peripheral blood iNKT cells in subjects that initiated ART in AHI (HIV uninfected n =19, Fiebig 1 n = 9, Fiebig II n = 9, and Fiebig III n = 7) 6 mo after ART. The lines and whiskers represent the median and interquartile range, respectively.