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. 2021 Nov 12;118(46):e2102206118. doi: 10.1073/pnas.2102206118

Fig. 6.

Fig. 6.

Gene-silencing of Csi-let-7a-5p in CsEVs ameliorates the biliary injuries. (A) The study design. The mice that were injected with scrambled-CsEVs (0.5 mg/mL, ∼100 μL) or inhibitor-CsEVs (0.5 mg/mL, ∼100 μL) at the indicated time courses. (B) The ratio of liver weight to body weight of mice (%). (C) The levels of serum indicators for biliary damages caused by scrambled-CsEVs or inhibitor-CsEVs; (D) Histological changes of livers from the mice administrated with scrambled-CsEVs or inhibitor-CsEVs were indicated by mHAI scores. The infiltrations of inflammatory cells in these mice are indicated by yellow arrows. (E and F) Ductal reactions were evaluated using the expression of CK19 (E) and Ki67 (F) as shown by IHC staining (yellow arrows). The values were expressed as mean ± SEM. Compared with indicated groups, *P < 0.05, **P < 0.01.