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. Author manuscript; available in PMC: 2021 Nov 23.
Published in final edited form as: J Invest Dermatol. 2011 Feb 24;131(6):1272–1279. doi: 10.1038/jid.2011.24

Figure 4. c-Jun N-terminal kinase (JNK) inhibitor blocks the tumor necrosis factor-α (TNF-α)-mediated inhibition of filaggrin (FLG).

Figure 4.

Primary human keratinocytes were pre-incubated with NF-κB inhibitor (10 nm, a), extracellular signal-regulated kinases 1/2 (ERK1/2) inhibitor (5 μm, b), p38 inhibitor (5 μm, c), and JNK inhibitor sp600125 (1 μm, d) before stimulation with TNF-α (20 ng ml−1). The gene expression of FLG was examined by real-time RT-PCR. **P<0.01; ***P<0.001. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.