. 2021 Oct 12;83(4):1825–1839. doi: 10.3233/JAD-210462

Table 4.

Summary of proteins with APOE+ PRS associations from meta-analyzed logistic regression with AD in all participants below Bonferroni significance

Protein	PRS p threshold^*	SNPs in PRS (N)	Beta^**	95%CI Lower	95%CI Upper	R^2 ***	p
APOE ɛ3	5.0E-08	5	0.26	0.20	0.31	0.01	6.5E-21
APOB-100	5.0E-08	2	0.58	0.46	0.70	0.01	6.7E-20
CRP	5.0E-08	5	–0.31	–0.42	–0.20	0.01	1.5E-08

^*p-value from protein GWAS below which SNPs were included in PRS. PRS p-value threshold for most significant PRS model (based on meta-analyzed p-value) presented. ^**Estimated based on normalized, per standard deviation of PRS. ^***Estimated from meta-analysis outputs using the formula $R^{2} = {(\frac{z}{\sqrt{n - 2 + z^{2}}})}^{2}$ where z is the Z-score for the protein PRS and n is the total sample size.