Fig. 1.

Multi-omics signatures of mesenteric adipose tissue in CD versus non-CD. a Separation of mesenteric microbiome between patients with 48 CD and 16 non-CD controls, revealed by principal component analysis (PCA) (Adonis p = 0.009). b LDA score computed from features differentially abundant between CD patients and non-CD controls. The criteria for feature selection is log LDA score > 3. c Separation of the mesenteric transcriptome between 46 CD patients and 15 non-CD controls, revealed by PCA (Adonis p = 0.001). d Heatmap of the immune-associated DEGs (FDR p < 0.05) from 46 patients with CD and 15 non-CD controls. Ordering by diagnosis, clustering within diagnosis. e Separation of mesenteric metabolome between 48 CD patients and 16 non-CD controls, revealed by PCA (Adonis p = 0.003). f Twenty-eight metabolites were significantly (Studentʼs t-test, p < 0.05) enriched in mAT from 48 CD, while 19 metabolites were significantly enriched in 16 non-CD controls. The violin plot indicated the difference of mean and 95% confidence interval for an individual metabolite. The statistical significance values are denoted as *p < 0.05, **p < 0.01, ***p < 0.001, **** p < 0.0001