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. 2021 Nov 23;28:79. doi: 10.1186/s12929-021-00774-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Single-cell transcriptomic analysis of the expression of Cdk5, Cdk5r1 (the gene encoding p35), and Cdk5r2 (the gene encoding p39) in young and aged mouse brain. The data are based on Ximerakis et al., 2019, Nat. Neurosci., and the graphs were generated by Single Cell Portal website (https://singlecell.broadinstitute.org/single_cell/study/SCP263/aging-mouse-brain). Astrocyte lineage: neural stem cells, astrocyte-restricted precursors and astrocytes. Ependymal cells: ependymocytes, hypendymal cells, tancytes, and choroid plexus epithelial cells. Immune cells: microglia, monocytes, macrophages, dendritic cells, and neutrophils. Neuronal lineage: neuronal-restricted precursors, immature neurons, mature neurons, and neuroendocrine cells. Vasculature cells: endothelial cells, pericytes, hemoglobin-expressing vascular cells, vascular smooth muscle cells, vascular and leptomeningeal cells, and arachnoid barrier cells