TABLE 2.

Signal discrimination for detection of the Mpro inhibitor (GC376)^a

Concn (μM)	n	Fluorescence		OD600		P b
		Ratio	SE	Ratio	SE
After 20 h
1	16	1.14	0.03	ND		7.0E–3
10	16	1.57	0.02	1.22	0.03	2.1E–11
30	20	2.28	0.03	1.61	0.03	2.2E–16
After 65 h
1	16	1.06	0.07	ND		0.5
10	16	1.20	0.02	1.19	0.03	0.64
30	20	1.49	0.02	1.55	0.03	0.068

^aCalculated as the ratio of yield compared to controls without inhibitor.

^bWelsh two-sample t test comparing yield ratios measured by fluorescence.