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. 2021 Nov 23;47(1):19–30. doi: 10.1007/s13318-021-00736-7
Products of Andrographis paniculata are available in multiple forms on the market, but the preparations are not yet well standardized to offer the expected effectiveness.
The diterpene lactones identified as active compounds in this species are poorly soluble in water and show slow dissolution rates. Their solubility behavior presents a major challenge to achieving a pharmacological effect.
Suitable pharmaceutical technologies improve the dissolution rate and oral bioavailability of diterpene lactones from A. paniculata formulations.