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. Author manuscript; available in PMC: 2021 Nov 23.
Published in final edited form as: Bioessays. 2017 Jul 4;39(8):10.1002/bies.201700076. doi: 10.1002/bies.201700076

Table 1.

Mutual exclusiveness of known synthetic lethal interactions

Synthetic lethal interactions Mutually exclusive patterns shown in cancer genetic database
Gene A Gene B
BRCA1 PARP1/PARP2 Prostate Adenocarcinoma (TCGA, Provisional; N=499)
ETS (ERG/ETV1) PARP1 Prostate Adenocarcinoma (TCGA, Provisional; N=499)
PTEN PLK4 Prostate Adenocarcinoma (TCGA, Cell 2015; N=333)
PTEN PARP1 Prostate Adenocarcinoma (TCGA, Cell 2015; N=333)
KRAS CDK1 Pan-Lung Cancer (TCGA, Nat Genet 2016; N=1144)
KRAS PLK1 Colorectal Adenocarcinoma (DFCI, Cell Reports 2016; N=619)
MTAP PRMT5 Pan-Lung Cancer (TCGA, Nat Genet 2016; N=1144)
VHL EPAS1 (HIF2a) Kidney Renal Clear Cell Carcinoma (TCGA, Provisional; N=538)
ATM PRKDC (DNAPK) Skin Cutaneous Melanoma (TCGA, Provisional; N=419)
MYC BRD4 Colorectal Adenocarcinoma (TCGA, Provisional; N=633)
MYC MTOR Colorectal Adenocarcinoma (TCGA, Provisional; N=633)
MYC CDK1 Prostate Adenocarcinoma (TCGA, Provisional; N=499)