FIG. 6.

Representative actograms illustrating rhythmic wheel-running behavior in a wild-type mouse (left) and an mPER3-deficient mouse (right). Each horizontal line represents a 48-h period; the second 24-h period is double plotted, appearing both to the right of and below the first 24-h period. Vertical deflections represent periods of wheel running. Animals were maintained in 12L:12D for the first 8 days of the record and then entered DD. The timing of the lighting cycle is indicated by the horizontal bar at the top. Records shown are from isogenic male mice from study 5 (Table 1).