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NLRP3 mutations association with ICI efficacy in distinct therapies. (A, B) Association of NLRP3 mutations with response rate and prognosis in patients treated with anti-CTLA-4 agents. (C, D) NLRP3 mutations versus response rate and prognosis in patients treated with anti-PD-1 agents. (E, F) NLRP3 mutations versus response rate and prognosis in patients who received combined therapy.
