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(p)ppGpp family, precursors and byproducts (Yang et al., 2020)- The RSH enzymes mediate the synthesis of pGpp, ppGpp and pppGpp by transfer of a pyrophosphate group to GMP/GDP/GTP. Further, interconversion of pppGpp to ppGpp is processed by guanosine pentaphosphatase (GppA) and translational GTPases (Hauryliuk et al., 2015).
