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. 2021 Nov 23;97(21):e2065–e2078. doi: 10.1212/WNL.0000000000012853

Figure 4. Association of CSF Synaptic Biomarkers With FDG PET AD Signature.

Figure 4

Scatterplots representing the association of each of the CSF synaptic biomarker with FDG PET uptake (standardized uptake value ratio) Alzheimer disease (AD) signature in the CSF β-amyloid (Aβ)–negative (A−; blue) and the CSF Aβ-positive (A+; red) groups. CSF Aβ status was defined by the CSF Aβ42/40 ratio, and participants were classified as CSF Aβ-positive if CSF Aβ42/40 <0.071. Each point depicts the value of the CSF biomarker of an individual, and the solid lines indicate the regression line for each of the groups. The associations were computed with a linear model adjusted for age and sex. GAP-43 = growth-associated protein-43; SNAP-25 = synaptosomal-associated protein-25.